Aspects of mirrors and suspensions for advanced gravitational wave detectors

Gravitational waves were first predicted by Albert Einstein's Theory of general relativity, published in 1916. These waves are perturbations in the curvature of space-time. Indirect evidence of their existence has been obtained via observations of binary pulsar system inspirals by Hulse and Taylor. Research is now focussed on achieving direct detection of gravitational waves, giving a new way of observing astronoomical events in the universe. Gravitational waves are quadrupole in nature, causing tidal strains in space. The weak nature of gravity means that the magnitude of these strains is very small. Only astronomical scale sources are likely to produce waves of sufficient amplitude to be detected on Earth. In the frequency band of a few Hz to a few kHz, the expected strain amplitude for violent sources is of the order of 10[superscript -22]. Detection is most likely to be achieved using long baseline interferometer detectors. Currently several such detectors are in operation worldwide, including the GEO600 detector, built in a collaboration involving the Institute for Gravitational Research at the University of Glasgow, the Albert Einstein Institute (Hannover and Golm), and the University of Cardiff. In America the LIGO detector network has three large interferometric detectors - two of 4 km arm length and one with 2 km arms. In Italy a European collaboration has constructed the 3 km VIRGO detector. Currently GEO600 and LIGO have undertaken 5 data taking science runs with the most recent year long run, also involving VIRGO, concluding in November 2007. No detections have yet been confirmed, but analysis on the results of the most recent GEO600/LIGO/VIRGO run is ongoing. These detectors are now operating at, or close to their design sensitivities, so research is focussed on reduction of various noise sources by upgrading of the detectors. One important noise source is thermal noise (both Brownian and thermo-elastic) - a limiting factor at midband frequencies. Reduction of mechanical loss in mirrors and their suspensions will help lessen the impact of thermal noise in future detectors. The research detailed in this thesis was aimed at reducing thermal noise. In particular, it covers work undertaken to investigate the mechanical loss of suspension ribbons and fibres, test mass mirror coatings and also diffractive surfaces on test masses to evaluate their suitability for employment in future advanced gravitational wave detectors. Upgrade of LIGO to "Advanced LIGO" will aim to reduce thermal noise by implementing mirror suspension techniques pioneered in GEO600. Specifically, it was initially proposed that test masses be suspended from silica ribbon fibres, a key choice that will be re-evaluated in this thesis. Ribbons (or fibres) will be fabricated by a CO[subscript 2] laser pulling machine being developed in Glasgow, with control programming being undertaken by the author. Characterising the dimensions, strength and vertical bounce frequencies of the ribbons is important to confirm their suitability for use in detector mirror suspensions. A dimensional characterisation machine was constructed to measure the ribbon's cross sectional dimensions, with emphasis being placed on achieving high resolution in the ribbon neck regions, where the most bending occurs. Also, a bounce testing machine was constructed to experimentally measure the ribbon's vertical bounce frequency. Finally a proof load test was constructed to verify that ribbons could support the required weight. Results showed that ribbons could be fabricated successfully with the required strength and bounce frequency, though shaping of the cross section still requires further research to achieve the optimum. In a pendulum system most of the energy is stored as gravitational potential energy rather than bending energy of the suspension fibres or ribbons. Thus the effective loss of the suspension fibres/ribbons is reduced or "diluted" and thermal noise is lower than may be naively expected. Dilution of the mechanical loss of the pendulum suspensions was investigated using finite element modelling. Methods for importing data from the dimensional characterisation machine were developed, and it was observed that the dilution resulting from ribbon suspensions was not as high as had been initially expected, with bending in the neck region of the ribbon being seen to significantly reduce dilution. It was observed that the rectangular ribbons had inferior dilution to equivalent cross section circular fibres for necks of the length typically being produced. A typical 7.5 mm necked ribbon was seen to have a dilution 1.5 times lower than an equivalent fibre, despite the ribbons having 3.3 times greater dilution with no necks. Ribbons were only seen to have this superior dilution for very short necks. Bending in the necks resulted in an increased amount of bending strain energy occurring which caused the lower dilution factors. Additionally, bending occurring in the ears that join the fibres or ribbons to the masses was seen to further reduce the dilution. In the light of low dilution factors, reduction (ideally nulling) of thermoelastic noise was studied. Reduction in thermal noise in this way is proposed through the use of tapered fibres, which showed that a lower overall noise level than that from the baseline ribbons planned for Advanced LIGO can be achieved, despite lower dilution factors. In the light of this work tapered fibres have now been adopted as the baseling for Advanced LIGO. Measurement of test mass mirror samples showed that the mechanical loss of mirror coatings can be significantly reduced by doping the high refractive index layer, with reduction up to a factor of 2.5 in measured mechanical loss observed, when compared to equivalent undoped coatings. In order to perform these measurements an interferometric read out system was constructed. Future detectors will use higher laser powers which may cause thermal distortions in transmissive optical components. Use of all reflective components may be required to reduce this problem, possibly via diffractive mirrors. Measurements were undertaken on samples to discover if introducing a diffraction grating to an optic's surface increased the mechanical loss. However, the grating was not seen to do this, and also did not increase the mechanical loss of an optical coating applied on top of its surface, which verified that diffractive optics are viable for use in future detectors

Design and sensitivity of a 6-axis seismometer for gravitational wave observatories

We present the design, control system, and noise analysis of a 6-axis seismometer comprising a mass suspended by a single fused silica fibre. We utilise custom-made, compact Michelson interferometers for the readout of the mass motion relative to the table and successfully overcome the sensitivity of existing commercial seismometers by over an order of magnitude in the angular degrees of freedom. We develop the sensor for gravitational-wave observatories, such as LIGO, Virgo, and KAGRA, to help them observe intermediate-mass black holes, increase their duty cycle, and improve localisation of sources. Our control system and its achieved sensitivity makes the sensor suitable for other fundamental physics experiments, such as tests of semiclassical gravity, searches for bosonic dark matter, and studies of the Casimir force

The 10m AEI prototype facility A brief overview

The AEI 10 m prototype interferometer facility is currently being constructed at the Albert Einstein Institute in Hannover, Germany. It aims to perform experiments for future gravitational wave detectors using advanced techniques. Seismically isolated benches are planned to be interferometrically interconnected and stabilized, forming a low-noise testbed inside a 100 m^3 ultra-high vacuum system. A well-stabilized high power laser will perform differential position readout of 100 g test masses in a 10 m suspended arm-cavity enhanced Michelson interferometer at the crossover of measurement (shot) noise and backaction (quantum radiation pressure) noise, the so-called Standard Quantum Limit (SQL). Such a sensitivity enables experiments in the highly topical field of macroscopic quantum mechanics. In this article we introduce the experimental facility and describe the methods employed, technical details of subsystems will be covered in future papers

Pregnancy in the mature adult mouse does not alter the proportion of mammary epithelial stem/progenitor cells

Introduction In humans, an early full-term pregnancy reduces lifetime breast cancer risk by up to 50% whereas a later pregnancy (>35 years old) can increase lifetime risk. Several mechanisms have been suggested, including changes in levels of circulating hormones, changes in the way the breast responds to these hormones, changes in gene expression programmes which may alter susceptibility to transformation and changes to mammary stem cell numbers or behaviour. Previous studies have shown that the mammary tissue isolated from both virgin and parous mice has the ability to repopulate a cleared mammary fat pad in transplant experiments. Limited dilution transplant assays have demonstrated that early pregnancy (at 5 weeks of age) reduces stem/progenitor cell numbers in the mouse mammary epithelium by twofold. However, the effects on stem/progenitor cell numbers in the mammary epithelium of a pregnancy in older animals have not yet been tested. Methods Mice were put through a full-term pregnancy at 9 weeks of age, when the mammary epithelium is mature. The total mammary epithelium was purified from parous 7-week post-lactation and age-matched virgin mice and analysed by flow cytometry and limiting dilution cleared fat pad transplants. Results There were no significant differences in the proportions of different mammary epithelial cell populations or numbers of CD24+/Low Sca-1- CD49fHigh cells (stem cell enriched basal mammary epithelial compartment). There was no significant difference in stem/progenitor cell frequency based on limiting dilution transplants between the parous and age-matched virgin epithelium. Conclusions Although differences between parous and virgin mammary epithelium at later time points post lactation or following multiple pregnancies cannot be ruled out, there are no differences in stem/progenitor cell numbers between mammary epithelium isolated from parous animals which were mated at 9 weeks old and virgin animals. However, a recent report has suggested that animals that were mated at 5 weeks old have a twofold reduction in stem/progenitor cell numbers. This is of interest given the association between early, but not late, pregnancy and breast cancer risk reduction in humans. However, a mechanistic connection between stem cell numbers and breast cancer risk remains to be established

Elevated plasma levels of cardiac troponin-I predict left ventricular systolic dysfunction in patients with myotonic dystrophy type 1:A multicentre cohort follow-up study

Objective: High sensitivity plasma cardiac troponin-I (cTnI) is emerging as a strong predictor of cardiac events in a variety of settings. We have explored its utility in patients with myotonic dystrophy type 1 (DM1). Methods: 117 patients with DM1 were recruited from routine outpatient clinics across three health boards. A single measurement of cTnI was made using the ARCHITECT STAT Troponin I assay. Demographic, ECG, echocardiographic and other clinical data were obtained from electronic medical records. Follow up was for a mean of 23 months. Results: Fifty five females and 62 males (mean age 47.7 years) were included. Complete data were available for ECG in 107, echocardiography in 53. Muscle Impairment Rating Scale score was recorded for all patients. A highly significant excess (p = 0.0007) of DM1 patients presented with cTnI levels greater than the 99th centile of the range usually observed in the general population (9 patients; 7.6%). Three patients with elevated troponin were found to have left ventricular systolic dysfunction (LVSD), compared with four of those with normal range cTnI (33.3% versus 3.7%; p = 0.001). Sixty two patients had a cTnI level < 5ng/L, of whom only one had documented evidence of LVSD. Elevated cTnI was not predictive of severe conduction abnormalities on ECG, or presence of a cardiac device, nor did cTnI level correlate with muscle strength expressed by Muscle Impairment Rating Scale score. Conclusions: Plasma cTnI is highly elevated in some ambulatory patients with DM1 and shows promise as a tool to aid cardiac risk stratification, possibly by detecting myocardial involvement. Further studies with larger patient numbers are warranted to assess its utility in this setting

A Cryogenic Silicon Interferometer for Gravitational-wave Detection

The detection of gravitational waves from compact binary mergers by LIGO has opened the era of gravitational wave astronomy, revealing a previously hidden side of the cosmos. To maximize the reach of the existing LIGO observatory facilities, we have designed a new instrument able to detect gravitational waves at distances 5 times further away than possible with Advanced LIGO, or at greater than 100 times the event rate. Observations with this new instrument will make possible dramatic steps toward understanding the physics of the nearby Universe, as well as observing the Universe out to cosmological distances by the detection of binary black hole coalescences. This article presents the instrument design and a quantitative analysis of the anticipated noise floor

A Cryogenic Silicon Interferometer for Gravitational-wave Detection

The detection of gravitational waves from compact binary mergers by LIGO has opened the era of gravitational wave astronomy, revealing a previously hidden side of the cosmos. To maximize the reach of the existing LIGO observatory facilities, we have designed a new instrument that will have 5 times the range of Advanced LIGO, or greater than 100 times the event rate. Observations with this new instrument will make possible dramatic steps toward understanding the physics of the nearby universe, as well as observing the universe out to cosmological distances by the detection of binary black hole coalescences. This article presents the instrument design and a quantitative analysis of the anticipated noise floor

Binary systems and their nuclear explosions

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Basic science232. Certolizumab pegol prevents pro-inflammatory alterations in endothelial cell function

Background: Cardiovascular disease is a major comorbidity of rheumatoid arthritis (RA) and a leading cause of death. Chronic systemic inflammation involving tumour necrosis factor alpha (TNF) could contribute to endothelial activation and atherogenesis. A number of anti-TNF therapies are in current use for the treatment of RA, including certolizumab pegol (CZP), (Cimzia ®; UCB, Belgium). Anti-TNF therapy has been associated with reduced clinical cardiovascular disease risk and ameliorated vascular function in RA patients. However, the specific effects of TNF inhibitors on endothelial cell function are largely unknown. Our aim was to investigate the mechanisms underpinning CZP effects on TNF-activated human endothelial cells. Methods: Human aortic endothelial cells (HAoECs) were cultured in vitro and exposed to a) TNF alone, b) TNF plus CZP, or c) neither agent. Microarray analysis was used to examine the transcriptional profile of cells treated for 6 hrs and quantitative polymerase chain reaction (qPCR) analysed gene expression at 1, 3, 6 and 24 hrs. NF-κB localization and IκB degradation were investigated using immunocytochemistry, high content analysis and western blotting. Flow cytometry was conducted to detect microparticle release from HAoECs. Results: Transcriptional profiling revealed that while TNF alone had strong effects on endothelial gene expression, TNF and CZP in combination produced a global gene expression pattern similar to untreated control. The two most highly up-regulated genes in response to TNF treatment were adhesion molecules E-selectin and VCAM-1 (q 0.2 compared to control; p > 0.05 compared to TNF alone). The NF-κB pathway was confirmed as a downstream target of TNF-induced HAoEC activation, via nuclear translocation of NF-κB and degradation of IκB, effects which were abolished by treatment with CZP. In addition, flow cytometry detected an increased production of endothelial microparticles in TNF-activated HAoECs, which was prevented by treatment with CZP. Conclusions: We have found at a cellular level that a clinically available TNF inhibitor, CZP reduces the expression of adhesion molecule expression, and prevents TNF-induced activation of the NF-κB pathway. Furthermore, CZP prevents the production of microparticles by activated endothelial cells. This could be central to the prevention of inflammatory environments underlying these conditions and measurement of microparticles has potential as a novel prognostic marker for future cardiovascular events in this patient group. Disclosure statement: Y.A. received a research grant from UCB. I.B. received a research grant from UCB. S.H. received a research grant from UCB. All other authors have declared no conflicts of interes

Case Reports1. A Late Presentation of Loeys-Dietz Syndrome: Beware of TGFβ Receptor Mutations in Benign Joint Hypermobility

Background: Thoracic aortic aneurysms (TAA) and dissections are not uncommon causes of sudden death in young adults. Loeys-Dietz syndrome (LDS) is a rare, recently described, autosomal dominant, connective tissue disease characterized by aggressive arterial aneurysms, resulting from mutations in the transforming growth factor beta (TGFβ) receptor genes TGFBR1 and TGFBR2. Mean age at death is 26.1 years, most often due to aortic dissection. We report an unusually late presentation of LDS, diagnosed following elective surgery in a female with a long history of joint hypermobility. Methods: A 51-year-old Caucasian lady complained of chest pain and headache following a dural leak from spinal anaesthesia for an elective ankle arthroscopy. CT scan and echocardiography demonstrated a dilated aortic root and significant aortic regurgitation. MRA demonstrated aortic tortuosity, an infrarenal aortic aneurysm and aneurysms in the left renal and right internal mammary arteries. She underwent aortic root repair and aortic valve replacement. She had a background of long-standing joint pains secondary to hypermobility, easy bruising, unusual fracture susceptibility and mild bronchiectasis. She had one healthy child age 32, after which she suffered a uterine prolapse. Examination revealed mild Marfanoid features. Uvula, skin and ophthalmological examination was normal. Results: Fibrillin-1 testing for Marfan syndrome (MFS) was negative. Detection of a c.1270G > C (p.Gly424Arg) TGFBR2 mutation confirmed the diagnosis of LDS. Losartan was started for vascular protection. Conclusions: LDS is a severe inherited vasculopathy that usually presents in childhood. It is characterized by aortic root dilatation and ascending aneurysms. There is a higher risk of aortic dissection compared with MFS. Clinical features overlap with MFS and Ehlers Danlos syndrome Type IV, but differentiating dysmorphogenic features include ocular hypertelorism, bifid uvula and cleft palate. Echocardiography and MRA or CT scanning from head to pelvis is recommended to establish the extent of vascular involvement. Management involves early surgical intervention, including early valve-sparing aortic root replacement, genetic counselling and close monitoring in pregnancy. Despite being caused by loss of function mutations in either TGFβ receptor, paradoxical activation of TGFβ signalling is seen, suggesting that TGFβ antagonism may confer disease modifying effects similar to those observed in MFS. TGFβ antagonism can be achieved with angiotensin antagonists, such as Losartan, which is able to delay aortic aneurysm development in preclinical models and in patients with MFS. Our case emphasizes the importance of timely recognition of vasculopathy syndromes in patients with hypermobility and the need for early surgical intervention. It also highlights their heterogeneity and the potential for late presentation. Disclosures: The authors have declared no conflicts of interes